Program always running

Today I opened a simulation wich was always working fine but now I have the problem that the VC says program is running so I can't do anything in the Simulation-Enviroment nor on the Controller side. Of course I pressed the Stop Button and I resarted several times but the VC always starts the program when coming up and there is no way to stop it. Program is even running when motors are off.
Any ideas how to get access to my Simulation?

Best regards
Michael